The entire fluid path is also stored in the sealed cartridge and requires less than 100 microliters of whole blood introduced either from a heparinized blood gas syringe, a capillary or a neutral tube with a tip applicator. The calibration solution is stored in a sealed cartridge and automatically released to perform a one-point calibration just before the sample analysis. This POC system uses a single-use disposable cartridge containing microsensors, a calibrator and a waste container. The i-STAT Alinity system is an easy-to-use portable blood analyzer that delivers test results in a few minutes. However, clinicians should interpret Po 2, creatinine and PT results with caution. The i-STAT Alinity appeared as a convenient device for measurements of numerous parameters. However, correlations of the PT and INR measurements with existing instruments were lower (R 2 = 86.0% and 89.7%), and biases in the Po 2 (7.9%), creatinine (5.4%) and PT (−6.6%) measurements were higher. We found that the within-lab coefficients of variation (CV) were very low ( 95%) correlated with those of the existing laboratory instruments, and the biases were very low (<2%) or low (2–5%). We assessed the imprecision and compared the results to those obtained on existing instruments in the central laboratory. We conducted an analytical performances study with the i-STAT Alinity device using cartridges CG4+ (pH, Pco 2, Po 2, lactate, bicarbonate and base excess) CHEM8+ (Na, K, Cl, ionized Ca, urea, creatinine, glucose, hematocrit and hemoglobin) and PT/INR (prothrombin time and international normalized ratio). Herein, we aimed to assess the analytical performances of the i-STAT Alinity system. However, data regarding their analytical performances in real-world situations remains scarce. Many Point-of-Care devices have been released over the past decade.
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